The current approach aimed in connecting the phenomena occurring within natural system to the conditions that outline the potential disclaim of a hypothesis, through the development of a methodological tool for the experimentation set-up. The outcome is a proposed procedure that shall allow for the identification of the conditions under which the phenomena have to be studied. In order to achieve that, we worked on the knowledge classification that provide a detailed de-structuring of the system into is main descriptors of experience, properties, qualities and characteristics for the main systemic categories of matter, energy, relationships and outcome. Each of these descriptors are to be expressed via physico-mathematical parameters applicable in the system, which are according to the expressed contributing properties/attributes. Thus eventually this procedure should be linking the descriptor to the properties of the contributors, for a potential disclaim of the hypothesis, when tested at certain conditions