As a crucial strategy for mitigating climate change and achieving electricity independence, renewable energy sources (RESs) are gaining widespread importance. This study explores achieving electricity autonomy for Nisyros Island, Greece, through RESs. Four scenarios are evaluated, including standalone wind and photovoltaic systems, alongside hybrid options combining both. Each scenario is designed to meet the island’s electricity demands while considering economic feasibility and minimal environmental impact. The research findings are that wind-based scenarios offer the most cost-effective solutions, with a three wind turbine setup emerging as the most economical option for full coverage of electricity demands. Hybrid approaches, particularly those incorporating more wind turbines, are also financially viable. Real-world consumption data are integrated into the analysis, providing valuable insights for Nisyros’ energy future. Overall, the study demonstrates Nisyros’ potential to achieve electricity independence through RESs, with wind resource assessments suggesting that the island could become autonomous. This approach would promote environmental sustainability by reducing the given dependence on fossil fuels. Additionally, it would bring economic benefits for the island’s residents in the renewable energy sector. Furthermore, this work allows for the island to achieve electricity independence through renewable energy in alignment with the EU’s climate goals.